A paper by Dr. Zachary Ferraro and his colleagues, “Role of leptin in pregnancy: Consequences of maternal obesity,” was recently published ahead of print in Placenta. Citation information is below.
Tessier DR, Ferraro ZM, Gruslin A. Role of leptin in pregnancy: Consequences of maternal obesity. Placenta. 2013 Jan 16. pii: S0143-4004(12)00470-5. doi: 10.1016/j.placenta.2012.11.035. [Epub ahead of print]
ABSTRACT: Maternal obesity is associated with increased risks of pregnancy complications. Excessive fat mass, common to obese women, has the potential to influence production and secretion of adipose tissue derived proteins called adipokines. The adipokine leptin is involved in the regulation of multiple aspects of maternal metabolic homeostasis. In addition, leptin has been shown to be important for placentation and maternal-fetal exchanges processes regulating growth and development. In later stages of a healthy pregnancy, central leptin resistance occurs to allow increased nutrient availability for the fetus. Disruption of the signaling capacity of leptin associated with obesity is emerging as a potential risk factor leading topregnancy complications as a result of aberrant fuel partitioning in utero. In this review we discuss the influence of obesity on the roles of leptin andleptin resistance at the central and placental level.
