Research Associate Dr. Zach Ferraro and visiting Brazilian scholar Dr. Nelson Nardo Jr. are authors on a paper, “Effects of exercise and metformin on the prevention of glucose intolerance: a comparative study,” that was recently published in the Brazilian Journal of Medical and Biological Research. Citation details and a summary of the paper are below.

Molena-Fernandes C, Bersani-Amado CA, Ferraro ZM, Hintze LJ, Nardo N Jr, Cuman RK. Effects of exercise and metformin on the prevention of glucose intolerance: a comparative study. Braz J Med Biol Res. 2015 Sep 29. pii: S0100-879X2015005053904. [Epub ahead of print]

ABSTRACT: We aimed to evaluate the effects of aerobic exercise training (4 days) and metformin exposure on acute glucose intolerance after dexamethasone treatment in rats. Forty-two adult male Wistar rats (8 weeks old) were divided randomly into four groups: sedentary control (SCT), sedentary dexamethasone-treated (SDX), training dexamethasone-treated (DPE), and dexamethasone and metformin treated group (DMT). Glucose tolerance tests and in situ liver perfusion were undertaken on fasting rats to obtain glucose profiles. The DPE group displayed a significant decrease in glucose values compared with the SDX group. Average glucose levels in the DPE group did not differ from those of the DMT group, so we suggest that exercise training corrects dexamethasone-induced glucose intolerance and improves glucose profiles in a similar manner to that observed with metformin. These data suggest that exercise may prevent the development of glucose intolerance induced by dexamethasone in rats to a similar magnitude to that observed after metformin treatment.

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