Congratulations to HALO Senior Scientist Dr. Mark Tremblay on his contributions to a new paper from the TARGet Kids! Collaboration titled “Predictive validity of the Infant Toddler Checklist in primary care at the 18-month visit and school readiness at 4 to 6 years” just published in Academic Pediatrics. Citation details and a summary of the paper are below.
Nurse, K. M., Janus, M., Birken, C. S., Keown-Stoneman, C. D. G., Omand, J. A., Maguire, J. L., Reid-Westoby, C., Duku, E., Mamdani, M., Tremblay, M. S., Parkin, P. C., Borkhoff, C. M., & TARGet Kids! Collaboration (2023). Predictive Validity of the Infant Toddler Checklist in Primary Care at the 18-month Visit and School Readiness at 4 to 6 Years. Academic pediatrics, 23(2), 322–328. https://doi.org/10.1016/j.acap.2022.09.004
Objective
The American Academy of Pediatrics recommends developmental surveillance and screening in early childhood in primary care. The 18-month visit may be an ideal time for identification of children with delays in language and communication, or symptoms of autism spectrum disorder (ASD). Little is known about the predictive validity of developmental screening tools administered at 18 months. Our objective was to examine the predictive validity of the Infant Toddler Checklist (ITC) at the 18-month health supervision visit, using school readiness at kindergarten age as the criterion measure.
Methods
We designed a prospective cohort study, recruiting in primary care in Toronto, Canada. Parents completed the ITC at the 18-month visit. Teachers completed the Early Development Instrument (EDI) when the children were in Kindergarten, age 4–6 years. We calculated screening test properties with 95% confidence intervals (CIs). We used multivariable logistic and linear regression analyses adjusted for important covariates.
Results
Of 293 children (mean age 18 months), 30 (10.2%) had a positive ITC including: concern for speech delay (n = 11, 3.8%), concern for other communication delay (n = 13, 4.4%), and concern for both (n = 6, 2.0%). At follow-up (mean age 5 years), 54 (18.4%) had overall EDI vulnerability, 19 (6.5%) had vulnerability on the 2 EDI communication domains. The ITC sensitivity ranged from 11% to 32%, specificity from 91% to 96%, false positive rates from 4% to 9%, PPV from 16% to 35%, NPV from 83% to 95%. A positive ITC screen and ITC concern for speech delay were associated with lower scores in EDI communication skills and general knowledge (β = −1.08; 95% CI: −2.10, −0.17; β = −2.35; 95% CI: −3.63, −1.32) and EDI language and cognitive development (β = −0.62; 95% CI: −1.25, −0.18; β = −1.22; 95% CI: −2.11, −0.58).
Conclusions
The ITC demonstrated high specificity suggesting that most children with a negative ITC screen will demonstrate school readiness at 4–6 years, and low false positive rates, minimizing over-diagnosis. The ITC had low sensitivity highlighting the importance of ongoing developmental surveillance and screening.
The full article is available here.
